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KMID : 0617319940040010015
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Journal of Pharmacetical Sceiences Ewha Womans University
1994 Volume.4 No. 1 p.15 ~ p.24
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The Effect of Eicosanoids on Cerebral Energy Metabolism and the Ca^++Concentration in Ischemic Rats
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Abstract
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We studied the effect of eicosanoids on the content of energy metabolites and the intrasynaptosomal Ca^++ (〔Ca^++〕_1) concentration in cerebral ischemic rats. An ischemic model was made by bilateral carotid artery ligation (BCAL) and by incubation of synaptosomes under aglycemic and N_2 gas bubbling condition. The content of ATP, creatine phosphate and glucose decreased at 15 minutes after BCAL while that of lactate increased in male Wistar rats. Oral administration of EPA(100 ㎎/㎖/㎏/day) or DHA(16 ㎎/㎖/㎏/day) for 6 weeks improved both the decreases and the increase of the cerebral energy metabolites. In addition, the increase of 〔Ca^++〕_1 under BACL was suppressed by EPA or DHA treatment. When the both Wistar rats and SHR were administered orally with EPA or DHA for 6 weeks, the effect on the increase of 〔Ca^++〕_1 under ischemia by N_2 gas bubbling were protected. From these results, it may be that EPA or DHA treatment were greatly contributed to preservation of ischemic cerebral energy metabolism and Ca^++ concentration.
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